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We manufacture the signals the body already uses to repair itself. Extracellular vesicles and patented long-acting growth factors, made to pharmaceutical standards.
Repair begins as a conversation between cells.
Clinics and brands come to us for the raw material of that conversation. Characterised vesicles, stabilised growth factors, and the documentation to stand behind them. What you build with it is yours.
Where it goes to work.
Every application draws on a defined set of characterised actives, with the evidence graded against each one.
Fifteen minutes.
That is roughly how long a native growth factor stays functional. AvaFactor™ carries a patented protective, stabilising fusion domain that extends it to weeks. It is the difference between an ingredient that survives your process and one that arrives already spent.
Comparison describes unmodified recombinant growth factors as a class, based on published half-life data. Figures refer to the active ingredient.
Made the way medicine is made.
Pharmaceutical standards
ISO 22716 GMP certified equipment and process control, with a Certificate of Analysis on every batch. Documentation arrives prepared for regulatory review.
Evidence you can check
Clinical findings are labelled clinical, mechanistic findings are labelled structure-function, and every paper is linked so your team can read it directly.
Two Nobel sciences
Growth factors took the 1986 prize in Medicine. Vesicle transport took the 2013 prize. We manufacture both and co-formulate them as one system.
From first note to documented batch.
Tell us the outcome
Describe what you are treating or formulating for. Knowing which molecule you want is our job, not yours.
Samples and specifications
Samples in your preferred format, liquid or lyophilised, with the full specification and Certificate of Analysis.
Evidence and regulatory pack
INCI names and identifiers, registration status for your market, and the underlying studies in full.
Quotation and supply
Indicative pricing against your volumes, then scheduled supply with batch documentation each time.
Bring us the outcome. We will bring the biology.
Samples, specifications, Certificate of Analysis, indicative pricing and minimum order quantity, within a few days.
Eight outcomes. One platform behind them.
Pick the result you are working toward and we will show you the actives that support it, the evidence tier for each, and what we can send you.
Not sure which applies?
Describe the treatment or product you have in mind and a formulation specialist will map it to the right actives.
Every active we supply.
Extracellular vesicles from plant and probiotic sources, recombinant growth factors, and the AvaFactor™ long-acting line. Each one INCI-registered or in application, characterised, and available liquid or lyophilised.
Show your work.
Every claim on this site traces back to a paper, and every paper is one click away. Read the methods, check the numbers, decide for yourself.
Three colours. They mean the same thing on every page.
Clinical
A human study, published and peer reviewed. We state the design, the number of participants and the trial registration, so you can see exactly what was tested and on how many people.
Structure-function
A mechanism shown in cells or in an animal model. This is what explains why an active works, and it is the layer your formulation rationale is built on.
Research stage
Early material where the published literature covers the ingredient class rather than our specific product. Flagged as such on the active's page, with the papers linked so you can judge them yourself.
The papers behind the platform.
Cica extracellular vesicle and growth-factor essence for hair and scalp ↗
A randomized, placebo-controlled clinical trial of a Cica extracellular-vesicle scalp essence combining long-acting recombinant IGF-1 and FGF-7. This is the strongest human evidence on the platform.
A 28-day pilot study of facial skin hydration, elasticity and texture ↗
An instrumented pilot of a Cica extracellular-vesicle serum. The treated group improved significantly across every measured parameter while the placebo group did not. The placebo arm was assembled post hoc rather than randomised alongside, which is why the study is labelled a pilot.
In vitro characterization of Centella asiatica extracellular vesicles and their skin-repair effects in a UVB-irradiated mouse model ↗
Characterisation and mechanism for ExoBella® Centella asiatica tissue-culture vesicles: antioxidant, anti-melanogenic, procollagen and barrier signalling.
FGF-7 and hair biology ↗ · IGF-1 in hair regeneration ↗
The mechanistic basis for the growth-factor line. FGF-7 activates FGFR2b to drive keratinocyte proliferation and the telogen to anagen transition; IGF-1 sustains the active growth phase through PI3K/Akt and suppresses the shedding signal.
Built to pharmaceutical standards.
Halyra™ is built on international pharmaceutical manufacturing infrastructure, with the process control and batch discipline that standard implies.
Cosmetics good-manufacturing-practice certified equipment and process control throughout.
Proprietary plant extracellular-vesicle separation and optimised tissue-culture conditions for yield and batch consistency.
Every line available liquid or lyophilised, with custom formats and concentrations on request.
INCI names and identifiers, Certificate of Analysis, and study references prepared for labelling and regulatory review.
Medical clinics and dermoclinics sourcing high-purity regenerative material for professional use, alongside cosmetic and supplement formulators building finished products. We supply the active and the documentation; what you build with it is yours.
Published work co-authored with the University of Pennsylvania and collaborators at Kyoto University CiRA, in Cosmetics, the International Journal of Molecular Sciences, and Current Issues in Molecular Biology.
Already inside products people buy.
Our actives are formulated into finished retail products, several of which have been through human clinical evaluation published in the peer-reviewed literature. Two of them are shown here.
A finished scalp essence, in market.
A retail scalp essence combining Cica extracellular vesicles with long-acting AvaFactor™ IGF-1 and FGF-7, taken through a randomized, placebo-controlled clinical trial and published in Cosmetics.
- AvaFactor™ IGF-1 →The regrowth signal. Tells the follicle to keep growing.
- AvaFactor™ FGF-7 →The thickening signal. Builds stronger structure.
- ExoBella® Cica →The calm-and-repair vesicle. Settles the scalp underneath.
This is the serum that went viral. When the trial was published it was picked up by the Daily Mail, earth.com and press around the world. The actives inside it are the ones on this page.
Day 0 and Day 56
Standardised photography from the randomized, placebo-controlled scalp-essence trial.
A finished facial serum, in market.
A retail facial serum built on Cica extracellular vesicles, assessed over 28 days. Hydration, elasticity, melanin, wrinkles, redness and pore size were each quantified with instrumental probes and a standardised imaging system.
- ExoBella® Cica →The calm-and-repair vesicle. Hydration, elasticity and tone, from a single characterised ingredient.
Day 0 and Day 28
Standardised facial imaging from the instrumented skin-quality pilot.
Individual results vary. Images illustrate the study protocol and are not a performance guarantee for any finished product.
A finished oral supplement, in market.
A daily eye-health capsule for heavy screen users. Our goji and turmeric vesicles are used here as the absorption layer, opening the route for the rest of the formula rather than sitting alongside it. This is the ingestible proof that the vesicle format survives digestion.
- ExoLycia™ →The recovery vesicle, from goji fruit.
- ExoCurma™ →The antioxidant workhorse, from turmeric root.
Users reported less eye fatigue, clearer vision, better hydration and greater overall comfort. A finished-product clinical study has been completed and is not yet published, so we present the consumer data only.
Want this system in your treatment or formulation?
Samples, specifications, Certificate of Analysis, indicative pricing and minimum order quantity, within a few days.
The body already knows how to repair itself.
The most powerful actives in regenerative science are borrowed from biology: the growth factors and extracellular vesicles your own cells use to signal repair. Here is what they are, in plain language, with the peer-reviewed detail one click below.
What is a growth factor?
A growth factor is a small protein carrying a single, specific instruction between cells. One says make more of yourself. Another says stop dividing. Another says build new blood vessels here. Cells are constantly listening for these signals and acting on them. It is how a cut knows to close and a follicle knows to grow.
There are hundreds. The ones behind skin and hair renewal include IGF-1, which keeps hair in its active growing phase, FGF-7 (also called KGF), which thickens and rebuilds, EGF, which renews the skin surface, and VEGF, which feeds tissue with fresh blood supply. Each is a different word in the same language of repair.
If a cell were a workshop, growth factors would be the work orders slipped under the door. Each one a short, precise instruction that sets the whole shop in motion.
Go deeper, the science
How the signal actually gets through
A growth factor binds a matching receptor on the cell surface. That binding changes the receptor's shape and switches on an internal relay, a signaling cascade, which ultimately changes which genes the cell is reading. The cell then does what the signal asked: divide, migrate, produce collagen, survive longer. The main relays in skin and hair are PI3K/Akt, MAPK/ERK and Wnt/beta-catenin.
The signals that matter here
- IGF-1, secreted by the dermal papilla at the base of the follicle. Drives and maintains anagen, the active growth phase, promotes follicle-cell proliferation, raises VEGF to build blood supply, and protects cells from apoptosis.
- FGF-7 (KGF), activates the FGFR2b receptor to drive keratinocyte proliferation, activate follicle stem cells and push the telogen to anagen transition. Works with IGF-1 and VEGF.
- EGF, accelerates epidermal renewal and supports barrier recovery. Widely used in post-procedure skin repair.
- TGF-beta1, remodels the extracellular matrix, collagen and fibronectin, for firmness and structure. Dose-sensitive: too much drives fibrosis, so it is formulated for controlled remodeling.
- VEGF, the master angiogenesis signal. Builds the microcirculation that feeds regenerating tissue.
Why they are hard to use, and how that is solved
Native growth factors are large, typically over 15 kDa, and fragile. Many have a functional half-life of only about 15 minutes. Left unprotected, a bare growth factor breaks down before it can work, and on its own it has no way to reach the living cells beneath the surface. Two things solve that. First, stabilisation: a protective, stabilising fusion domain that extends functional half-life to weeks, which is our patented AvaFactor™ platform. Second, co-formulation with extracellular vesicles, so the stabilised factor and the vesicle are supplied and delivered together as one system.
What is an extracellular vesicle (exosome)?
An extracellular vesicle is a bubble so small you could line up roughly a thousand across a single human hair. Cells make them constantly to send messages to one another, packing proteins, signals and genetic instructions inside a protective membrane and releasing them into the space between cells.
Because the cargo is sealed inside, it survives the journey and is delivered into the receiving cell intact. That is the entire point of a vesicle: it reaches places where a bare molecule on the surface would break down long before it arrived.
Plants and probiotic bacteria build their own extracellular vesicles too, and those are the ones we cultivate. A plant's antioxidants and signals, delivered in that same protected way.
A growth factor on its own is a letter in the rain. An extracellular vesicle is the sealed, waterproof envelope that gets it there dry.
Go deeper, the science
Structure
- Size, 30 to 150 nm. Nanoscale, far smaller than a cell at roughly 10,000 to 20,000 nm.
- Membrane, a lipid bilayer, the same material that forms cell membranes. Biocompatible and low immunogenicity.
- Surface markers, tetraspanins (CD9, CD63, CD81) and adhesion molecules that help them dock onto recipient cells.
- Cargo, proteins, messenger and micro-RNA, and lipids. The actual message.
Why plant and probiotic vesicles matter
Plants and probiotic bacteria produce their own extracellular vesicles. For professional and cosmetic use they are attractive because the vesicle shields bioactive cargo, polyphenols, RNA and peptides, through processing and, for ingestibles, through digestion. We characterise ours by nanoparticle tracking analysis for particle count and size distribution, following MISEV2023 guidance.
A note on the word
You will see these called exosomes. Strictly, exosome describes a specific biogenesis route in animal cells, and plants do not make exosomes in that narrow sense. We say extracellular vesicle throughout because it is the accurate term.
The idea that reframed regenerative medicine
For decades the promise of stem cells was simple: implant them, and they will become new tissue. But when researchers looked closely at why stem-cell treatments helped, they found something unexpected. Much of the healing did not come from stem cells becoming new cells at all. It came from what they secreted. The cells were healing their neighbours by talking to them.
That released mixture of growth factors, extracellular vesicles and other signalling molecules drives the effect, and the mechanism is called paracrine signalling. Paracrine simply means acting on nearby cells. It carries a powerful implication: you may not need the cells at all. Capture and deliver the signals, and you can guide repair directly.
That is the foundation Halyra™ is built on. Instead of cell therapy, we manufacture the messages themselves: defined growth factors and characterised extracellular vesicles, made to pharmaceutical standards, ready to use.
Go deeper, the science
The paracrine hypothesis, and the word for it
The full set of molecules a cell releases to talk to its neighbours has a technical name, the secretome. You will meet it in the literature, so it is worth knowing, though we describe what we supply as regenerative actives rather than as a secretome product. Across a large body of pre-clinical work, mesenchymal stem cells were found to exert much of their therapeutic effect not by engrafting and differentiating into new tissue but through paracrine factors they secrete: growth factors, cytokines and extracellular vesicles. A systematic review of pre-clinical cardiovascular studies catalogues how these secreted factors, rather than the cells themselves, drive repair.
Why this matters commercially
It underwrites a cell-free regenerative approach. Rather than the regulatory and stability burden of living cells, you can work with defined, characterised components, exactly the extracellular vesicles and growth factors we supply, in a form that is reproducible and quantifiable batch to batch.
Two Nobel sciences, one platform
The two messengers each trace back to a Nobel Prize. The discovery that specific proteins instruct cells to grow, growth factors, won the 1986 Nobel Prize in Medicine and has since appeared in more than 39,000 studies. The machinery that lets cells package and ship those signals in vesicles won the 2013 Nobel Prize in Medicine, with 5,200 studies and counting.
Very few suppliers work with either. Halyra™ supplies both, and does the thing at the frontier of the field: co-formulating growth factors with extracellular vesicles so the message and the messenger arrive as one system.
The questions everyone asks
Are extracellular vesicles the same as stem cells?
No. Extracellular vesicles are cell-free messengers, nanoscale vesicles that cells secrete. We do not supply living cells. The whole premise, the paracrine idea in chapter 3, is that you can get much of the benefit of stem-cell biology by delivering the secreted signals instead of the cells, which is far more reproducible, stable and workable.
Are plant extracellular vesicles really exosomes?
Not in the strict sense, and the distinction is worth knowing. Exosome describes one specific biogenesis route inside animal cells. Plants and bacteria build their own nanoscale vesicles by their own routes, structurally and functionally similar, carrying cargo inside a protective lipid membrane. Functionally they do the same job. Terminologically they are extracellular vesicles, which is the word we use throughout. Ours are INCI-registered and characterised by nanoparticle tracking analysis.
What is the difference between a vesicle and a growth factor?
A growth factor is the message, a protein carrying an instruction. An extracellular vesicle is the messenger, a vesicle that carries cargo safely between cells. They operate at different levels and they work well together. In our system the stabilised growth factor and the vesicle are co-formulated as one system, supplied together rather than one placed inside the other.
Do growth factors and vesicles survive in a finished product?
Different answers for the two.
Vesicles are inherently robust. That is the whole point of a lipid bilayer. The published literature on plant-derived vesicles shows cargo surviving processing and, for ingestibles, gastrointestinal transit, which is precisely why the format is attractive for formulation.
Native growth factors are the fragile ones. Many lose activity within about 15 minutes. That is exactly the problem AvaFactor™ solves, with a patented protective, stabilising fusion domain that extends functional half-life from minutes to weeks. It is the difference between a label that says it contains growth factors and one where they are still active when the product reaches the skin.
Can I make claims on-pack or in my clinic?
Yes, with the right groundwork. Permitted wording differs by region, so the claim that works in one market is rarely word-for-word the claim that works in another. We hand your regulatory team the full ingredient evidence and the underlying studies, and we work through the wording with you directly when we talk.
Are these vegan or animal-free?
Every active listed on this site is plant-derived, microbe-derived or expressed in a bioreactor. The botanical vesicles come from plant tissue culture, the probiotic vesicles from bacterial culture, and the recombinant growth factors are produced in bioreactors rather than sourced from animals. If you need a formal declaration for a specific active, ask and we will issue one against the batch.
How do we start working with you?
Through a simple quotation model. Tell us the outcome you are working toward and we send samples, specifications and a Certificate of Analysis, then indicative pricing and minimum order quantity. You can request a quotation whenever you are ready, or browse the actives first.
Now put the science to work.
Bring us the outcome you need to deliver and we will bring the active, the data and the specification.
Tell us what you are working on.
Send the outcome or the actives you are interested in and we will come back with samples, specifications, Certificate of Analysis, indicative pricing and minimum order quantity.